Opis

Protein prenylation involves the addition of a farnesyl (C15) or geranylgeranyl (C20) isoprenoid moiety onto a cysteine residue located near the carboxyl terminal of a protein. This posttranslational modification occurs at the C-terminus of approximately 2% of all mammalian proteins. Different classes of proteins, among them the family of Ras proteins, are known to be farnysylated. Prenylation is an important process to mediate protein-protein interactions and protein-membrane interactions. A recently discovered application of prenylated peptides is that they have inherent cell-penetrating ability.

Prenylation of peptides requires the addition of a lipid chain formed by three (farnesyl) or 4 (geranylgeranyl) isoprene units to a free thiol group. The synthesis of peptides containing farnesyl or geranylgeranyl groups is severely hampered by the pronounced acid-lability of these groups, in particular of the double bonds which are all transconfigured in the farnesyl and geranylgeranyl chains. We have developed a reliable procedure for the synthesis of prenylated peptides, and therefore is able supply these peptides at the request of its customers.

 

Name Structure
Farnesyl
Geranyl

Recenzje

Na razie nie ma opinii o produkcie.


Tylko zalogowani klienci, którzy kupili ten produkt mogą napisać opinię.