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- One-on-one managing of each project
- Process optimization of synthetic route
- Highly ensured purity at >95%
|Standard Peptide Synthesis||Large Scale Peptide Production|
|Quantity||Up to 100 gram||Up to 1 kilogram|
|Length||More than 100aa||More than 100aa|
|Parameter Qualification & Report|
|Free Sample Preparation|
|Customized Analysis Testing|
|Analytical Method Development|
|Cusomer-requested Package & Delivery|
|Customer Depending Features|
Large-Scale Liquid (Solution) Phase Peptide Synthesis (LPPS)
LPPS is the technology of choice for manufacturing short peptides or structures that are inappropriate for a resin matrix. This approach ultimately provides a cost-effective process for large-scale manufacture of multi-kg.
Large-Scale Solid Phase Peptide Synthesis (SPPS)
SPPS is the technology of choice for manufacturing most peptides in up to multi-10 kg quantities, especially those with longer, more complex sequences. Novazym offer both Fmoc- and tBoc-based solid-phase manufacturing.
Large-Scale Hybrid Fragment Synthesis
This technology, which involves coupling shorter, SPPS generated sequences together in solution, is particularly suitable for some longer peptide structures, offering higher yields than straight-through SPPS.
Modern preparative high-pressure liquid chromatography (HPLC) technology has greatly facilitated the bulk manufacture of high purity peptides, suitable for pharmaceutical applications. Thanks to the available technology, the latest equipment and high level expertise, we are capable of achieving the necessary purity of products at almost any scale, from milligrams to kilograms or more.
Purification is usually performed by liquid-phase chromatography, using
- reverse-phase HPLC with columns up to 30 cm in diameter;
- ion exhange chromatography with columns up to 1 meter in diameter;
- size exclusion chromatography up to 1 meter in diameter.