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Description
Studies on NMA (N-methylamino acid) containing peptides reveal that NMA residues increase proteolytic stability, increase membrane permeability (lipophilicity), and alter the conformational characteristics or properties of the amide bonds. A review by Fairlie discusses many aspects of the biological activity of peptides including numerous examples of N-methylation in natural products and therapeutic agents. The effects of NMA mentioned above are important in actual and potential therapeutic compounds and the assay of biological activity of modified peptides.
Short Name | CAS # | Molecular Formula | Molecular Weight |
N-Me-Val-OH | 2480-23-1 | C6H13NO2 | 131.18 |
N-Me-Tyr-OH | 537-49-5 | C10H13NO3 | 195.22 |
N-Me-Trp-OH | 526-31-8 | C12H14N2O2 | 218.26 |
N-Me-Thr-OH | 2812-28-4 | C5H11NO3 | 133.15 |
N-Me-Ser-OH | 2480-26-4 | C4H9NO3 | 119.12 |
N-Me-Pro-OH | 475-11-6 | C6H11NO2 | 129.2 |
N-Me-Phe-OH | 2566-30-5 | C10H13NO2 | 179.22 |
N-Me-Orn-OH•HCl | 37148-99-5 | C6H14N2O2 | 182.65 |
N-Me-Nva-OH | 19653-78-2 | C6H13NO2 | 131.18 |
N-Me-Nle-OH | 17343-27-0 | C7H15NO2 | 145.2 |
N-Me-Met-OH | 42537-72-4 | C6H13NO2S | 163.2 |
N-Me-Lys-OH | 7431-89-2 | C7H16N2O2 | 160.22 |
N-Me-Leu-OH | 3060-46-6 | C7H15NO2 | 145.2 |
N-Me-Ile-OH | 4125-98-8 | C7H15NO2 | 145.2 |
N-Me-Hyp-OH | 67463-44-9 | C6H11NO3 | 145.16 |
N-Me-His-OH•HCl | 17451-62-6 | C7H11N3O2 | 205.6 |
N-Me-Gly-OH | 107-97-1 | C3H7NO2 | 89.1 |
N-Me-Glu-OH | 6753-62-4 | C6H11NO4 | 161.16 |
N-Me-Gln-OH | 300560-56-9 | C6H12N2O3 | 160.2 |
N-Me-Asp-OH | 4226-18-0 | C5H9NO4 | 147.13 |
N-Me-Asn-OH | C5H10N2O3 | 146.1 | |
N-Me-Arg-OH•HCl | C7H16N4O2S | 224.7 | |
N-Me-Ala-OH | 3913-67-5 | C4H9NO2 | 103.1 |
N-Me-Aib-OH | 2566-34-9 | C5H11NO2 | 117.15 |
Fmoc-N-Me-Cys(Trt)-OH | 944797-51-7 | C38H33NO4S | 599.7 |
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